Table 1.
Body weight (g) did not differ among WT, ARG1+/−, and ARG2−/− mice in uninephrectomized (WT Sham) or DOCA-salt treated mice.
| WT Sham | WT DOCA | ARG1+/−Sham | ARG1+/−DOCA | ARG2−/−Sham | ARG2−/−DOCA | |
|---|---|---|---|---|---|---|
| Body weight (g) | 27 ± 2 | 27 ± 1 | 26 ± 3 | 25 ± 2 | 27 ± 2 | 26 ± 2 |
| Aorta Emax (%) | 98 ± 1 | 101 ± 3 | 97 ± 1 | 93 ± 2 | 96 ± 2 | 95 ± 3 |
| Aorta pEC50 | 8.26 ± 0.07 | 8.37 ± 0.09 | 8.14 ± 0.09 | 8.09 ± 0.07 | 8.10 ± 0.07 | 8.17 ± 0.06 |
| MA Emax (%) | 100 ± 2 | 103 ± 2 | 101 ± 2 | 99 ± 1 | 101 ± 1 | 98 ± 2 |
| MA pEC50 | 8.40 ± 0.05 | 8.51 ± 0.06 | 8.33 ± 0.08 | 8.26 ± 0.09 | 8.43 ± 0.05 | 8.37 ± 0.09 |
The maximal effect (Emax) and potency (pEC50) values obtained from concentration-response curves to a nitric oxide donor, sodium nitroprusside (SNP, 0.0001–3 μM) in aorta and second-order branches of mesenteric arteries (MA) from WT, ARG1+/−, and ARG2−/− mice in uninephrectomized (WT Sham) or DOCA-salt treated mice. Data represent the means ± SEM of four experiments.