Table 3.

Estimated Change in Medication Adherence 12 Months before and 12 Months after the Actual Copayment Increase from Four Different Inclusion Criteria in “Different Criteria, Same Time” Analysis

	Estimated Adherence 12 Months before Copay Change	Estimated Adherence 12 Months after Copay Change	Estimated Change in Adherence	Bootstrapped 95% Confidence Interval
Original approach (3&9)	61.9%	66.5%	4.6%	3.3%, 6.0%
Alternative #1 (2 in 12)	59.2%	60.1%	0.9%	−0.2%, 2.0%
Alternative #2 (6&6)	64.1%	64.4%	0.3%	−0.7%, 1.4%
Alternative #3 (2 in 6)	60.3%	66.4%	6.1%	4.7%, 7.4%

Note: Adherence was defined as the proportion of adherent patients.