Table 2.

Significantly changed genes Illumina Gene Array experiment

Gene ID	Fold Change	Adj P Value	Gene Symbol	Definition
5860358	0.6351	0.0107	Vegfa	Vascular endothelial growth factor A transcript variant 1
2230730	0.6586	0.0107	Gjb2	Gap junction membrane channel protein β2
780554	0.6564	0.0136	Sema7a	Semaphorin 7A
70341	1.4599	0.0136	Txnip	Thioredoxin-interacting protein 2
6520075	0.7039	0.0234	Ier3	Immediate early response 3
3130059	0.6857	0.0234	Lif	Leukemia inhibitory factor transcript variant 2
20612	0.6842	0.0234	Egr3	Early growth response
4050762	0.6796	0.0243	Serpinb2	Serpin peptidase inhibitor clade B (ovalbumin) member 2
3840040	0.7195	0.0414	Grasp	General receptor for phosphoinositides 1 associated scaffold protein
7050138	0.7348	0.0414	Gfod1	Glucose fructose oxidoreductase domain containing 1

3T3-CrT cells were incubated in the presence of 5 mM creatine for 3 h before analysis of total RNA using a global gene array approach with Illumina Beadchips. Saturating Cr concentration led to upregulation of Txnip by 46% compared with untreated cells (n = 3 each treatment; P = 0.013). Adj P value, P value after multiple corrections test.