Assessment of thyroid hormone action in multiple tissues. Expression of thyroid hormone-responsive genes after GC-1 treatment (A) or KB-2115 treatment (B). Genes examined: deiodinase 1 in liver, hairless in white adipose tissue, hairless in skeletal muscle, deiodinase 2 in skeletal muscle, sarcoendoplasmic reticulum Ca2+-ATPase (SERCA) 1 in skeletal muscle, and malic enzyme 1 (ME1) in skeletal muscle (open bars, vehicle; filled bars, thyromimetic; *P < 0.04 vs. vehicle; **P < 0.04 vs. vehicle; ***P < 0.0004 vs. vehicle).