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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: Annu Rev Med. 2012;63:131–145. doi: 10.1146/annurev-med-062909-130018

Figure 2.

Figure 2

Manhattan plot of data derived from 974 HIV controllers and 2,648 progressors. Shown are p-values for 1,384,048 data points derived from comparing each measured single-nucleotide polymorphism (SNP) in HIV controllers versus progressors. 313 SNPs reach statistical significance in this population of European ancestry, appearing as a line, which is defined by p < 5 × 10−8 because of the need to correct for multiple comparisons. All significant SNPs lie within the major histocompatibility complex on chromosome 6.