LC separation of derivatized products of five synthesized HS-like oligosaccharides by reverse-phase C18 column packed with either traditional porous material (A) or fused core-porous shell material (B). Same colors in two chromatograms represent the same oligasaccharide as indicated on the right side. For porous C18 column (50mm, 200Å, 3μm): 4 of the 5 oligosaccharides were separated, with NS-hendecamer and NS-decamer co-eluted at 45.29min. For core-shell Halo C18 column (50mm, ~160Å, ~2.6μm): 5 oligosaccharides were able to be separated from each other or at least partially separated.