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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: J Proteome Res. 2012 Nov 7;11(12):5630–5641. doi: 10.1021/pr300598t

Figure 7.

Figure 7

Benchmarking knock-in AP-MS against known interactions. (A) The proportion of interactions identified that are already known (BioGRID) vs the bait/control p-value for the APC (unfractionated) replicated data sets. At p < 0.05, approximately 1/3 of proteins identified are known APC interactions according to BioGRID. (B) Overlap between APC BioGRID interactions and proteins identified using knock-in AP-MS (all proteins with bait/control ratio ≥2), with or without prior subcellular fractionation. Proteins in bold were also identified as APC interactors in the Bandyopadhyay et al.34 study using yeast two-hybrid.