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. 2013 Apr 3;305(2):C147–C159. doi: 10.1152/ajpcell.00037.2013

Fig. 5.

Fig. 5.

Enhancement of PIPn sensitivity by L633P depends on the NH2-terminal PIPn regulation site of CNGA3. A: cartoon showing the PIPn regulation site within the NH2-terminal region of CNGA3; neutralization of the seven arginines within this region (N7R-A) is sufficient to prevent PIPn regulation of the channel. B: representative cGMP dose-response relationships before (black) and after (gray) 10 μM PIP2 for activation of homomeric A3–613X (Δ613–694), A3 N7R-A,613X, A3 N7R-A,L633P channels, and heteromeric A3 N7R-A, L633P + B3 channels.