Fig. 3.

The selective M₃-R antagonist 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) suppresses the carbachol inhibitory effects on the STBKC amplitude and frequency in freshly isolated rat DSM cells. A: a representative recording of a freshly isolated DSM cell illustrating the lack of both carbachol-evoked large transient outward BK currents and carbachol inhibitory effects on the STBKC amplitude and frequency in the presence of 0.1 μM 4-DAMP. B: summarized data illustrating the lack of carbachol inhibitory effects on the amplitude and frequency of STBKCs in the presence of 4-DAMP (n = 5, N = 5; P > 0.05). Average amplitude and frequency of STBKCs in the presence of 4-DAMP were taken to be 100% (control), and data were normalized to controls.