Fig. 2.

Hyperoxia-induced recruitment of inflammatory cells and elevation of monocyte chemoattractant protein-1 (MCP-1) were attenuated in NLRP3^−/− mice. WT and NLRP3^−/− mice were exposed to room air or 100% O₂ for 72 h and euthanized, and bronchoalveolar lavage fluid (BALF) was collected. A: total cell counts. B: total number of macrophages. Results of A and B (means ± SE; n = 4 in each group) are representative of 2 independent experiments. C: levels of MCP-1 were measured by ELISA. Results (means ± SE; n = 4 in each group for normoxia; n = 8 in each group for hyperoxia) are cumulative data of 2 independent experiments. *P < 0.05 **P < 0.01.