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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: J Vet Pharmacol Ther. 2010 Aug;33(4):315–322. doi: 10.1111/j.1365-2885.2010.01160.x

Figure 1.

Figure 1

Structure of nicotinic acetylcholine receptors (nAChRs). (a) nAChRs are pentameric macromolecules composed of five homomeric subunits or heteromeric subunits arranged around a central cation (Na+, K+, and Ca2+) permeable pore. (b) Each subunit includes four transmembrane (TM1-TM4) domains with TM2 lining the ion channel and a potential phosphorylation site between TM3 and TM4 (Modified from Thany et al., Trends Pharmacol Sci 2007;28:14–22, Figure 1 with permission).