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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: J Vet Pharmacol Ther. 2010 Aug;33(4):315–322. doi: 10.1111/j.1365-2885.2010.01160.x

Table 1.

Specificity of imidacloprid, nitenpyram and dinotefuran for insect and vertebrate α4β2 nicotinic receptors (Modified from Tomizawa M, Casida JE. Annu Rev Pharmacol Toxicol 2005;45:247–268, Table 4 with permission).

IC50, nM
Compound Insect Vertebrate α4β2 Selectivity ratio
Imidacloprid 4.6 2600 565
Nitenpyram 14 49,000 3500
Dinotefuran 900 >100,000 >111

IC50 values for displacing [3H]imidacloprid binding to the fruit fly (Drosophila melanogaster) receptor and [3H]nicotine binding to the vertebrate α4β2 nAChR.12