Skip to main content
. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: Neuroscience. 2012 Aug 9;225:1–8. doi: 10.1016/j.neuroscience.2012.07.069

Fig. 3.

Fig. 3

Deletion of STEP facilitates induction of LTP in LA without affecting basal synaptic transmission. (A) Basal synaptic transmission and LTP in STEP−/− mice. Synaptic responses to increasing stimulus intensity (upper left panel). The fEPSP amplitude is plotted as a function of stimulus intensity in slices from WT mice (n = 9 slices, 3 mice, black circles) or from STEP−/− (KO) mice (n = 11 slices, 3 mice, open circles). (B) Paired synaptic responses from WT and STEP−/− slices at different interstimulus intervals do not differ (upper right panel). Ratio of the second fEPSP the first fEPSP (mean ± SEM) is plotted for WT (n = 9 slices, 3 mice, black circles) and STEP−/− mice (n = 11 slices, 3 mice, open circles). (C) Pooled fEPSP amplitude (lower panel) (mean ± SEM) is plotted for WT slices (n = 9 slices, 3 mice, black circles) and STEP−/− slices (n = 10 slices, 3 mice, open circles circles). Tetanic stimulation was delivered at t = 20 min as indicated by the arrow.