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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Am J Med Genet C Semin Med Genet. 2013 Jul 10;163(3):144–156. doi: 10.1002/ajmg.c.31369

Figure 3.

Figure 3

Hypertrabeculation and noncompaction in FKBP12-deficient hearts. A and B, Cardiac histology of wild-type (A) and FKBP12-deficient heart (B) at E14.5. Black arrow denotes persistent trabecular myocardium in FKBP12 mutant heart. LV, left ventricle; RV, right ventricle; VS, ventricular septum; VSD, ventricular septal defect. C and D, Marked increase of cardiomyocyte proliferation in FKBP12 mutant heart. Immunohistochemical analysis of anti-Ki67 immune reactivity; the dark-brown nuclear signals are positive for Ki67, indicating proliferating cells. E and F, Disrupted cardiomyocyte polarization and myofibrillogenesis in FKBP12 mutant trabecular myocardium. Immunofluorescence staining using anti-α-actinin and anti-α-actin antibody, white arrows denote well organized sarcomeres in elongated normal trabecular cardiomyocytes.