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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Am J Med Genet C Semin Med Genet. 2013 Jul 10;163(3):144–156. doi: 10.1002/ajmg.c.31369

Figure 6.

Figure 6

Hypothetical model for the pathogenesis of ventricular hypertrabeculation and noncompaction. Two independent signaling pathways are associated with ventricular hypertrabeculation and noncompaction, in which abnormal regulation of cardiomyocyte proliferation (i.e., BMP10-mediated pathway) underlies the development of hypertrabeculation, while abnormal regulation of cardiomyocyte polarity and myofibrillogenesis (i.e., Daam1-mediated function) underlies the development of ventricular noncompaction.