Table 2.
Effect of the MTNR1B rs10830963 on insulin secretion in the studied cohorts.
| Study | Phenotype | Genotypes | Additive model |
|||||
|---|---|---|---|---|---|---|---|---|
| CC | CG | GG | RA | BETA | SE | P Value | ||
|
DGI WGAS (OGTT n=1,020) |
Age (yrs) | 59±10 | 59±10 | 58±10 | - | 0.74 | ||
| BMI (kg/m2) | 26.5±3.6 | 26.7±4.0 | 27.3±3.7 | - | 0.14 | |||
| Fasting P-glucose (mmol/l) | 5.28±0.53 | 5.32±0.52 | 5.38±0.60 | 0.31 | 0.045 | 0.022 | 0.039 | |
| CIR (mUxL/mmol2) | 180±360 | 165±1912 | 144±163 | −0.166 | 0.048 | 7×10−4 | ||
| DI (mU3/L3) | 24036±29445 | 20285±27763 | 16555±22974 | −0.173 | 0.046 | 2×10−4 | ||
|
Botnia PPP (OGTT n=3,300) |
CC | CG | GG | |||||
| Age (yrs) | 48.3±16.0 | 48.5±15.9 | 49.6±15.9 | - | 0.38 | |||
| BMI (kg/m2) | 26.12−4.21 | 26.22−4.22 | 26.19−3.82 | - | 0.79 | |||
| Fasting P-glucose (mmol/l) | 5.06±0.54 | 5.25±0.55 | 5.28±0.55 | 0.30 | 0.134 | 0.014 | 2×10−22 | |
| CIR (mUxL/mmol2) | 271±415 | 205±245 | 175±134 | −0.170 | 0.021 | 5×10−16 | ||
| DI (mU3/L3) | 44631±87537 | 30499±49947 | 24316±21582 | −0.241 | 0.022 | 1×10−26 | ||
|
Botnia prospective (OGTT n=2,444) |
Baseline | CC | CG | GG | ||||
| Age (yrs) | 45.8±13.2 | 45.1±13.8 | 45.6±14.2 | - | 0.52 | |||
| BMI (kg/m2) | 25.5±4.1 | 25.7±3.7 | 25.7±3.8 | - | 0.48 | |||
| Fasting P-glucose (mmol/l) | 5.47±0.57 | 5.55±0.57 | 5.64±0.54 | 0.29 | 0.081 | 0.019 | 1×105 | |
| CIR (mUxL/mmol2) | 176±183 | 150±164 | 129±137 | −0.160 | 0.026 | 6×10−10 | ||
| DI (mU3/L3) | 302±361 | 254±306 | 224±212 | −0.171 | 0.026 | 9×10−11 | ||
| Follow-up | CC | CG | GG | |||||
| Age (yrs) | 53.8±13.8 | 52.7±14.3 | 53.3±14.9 | - | 0.25 | |||
| BMI (kg/m2) | 26.5±4.1 | 26.7±4.2 | 26.7±4.2 | - | 0.41 | |||
| Fasting P-glucose (mmol/l) | 5.25±0.56 | 5.34±0.56 | 5.41±0.61 | 0.086 | 0.019 | 5×10−6 | ||
| CIR (mUxL/mmol2) | 234±238 | 188±192 | 145±125 | −0.188 | 0.026 | 1×10−12 | ||
| DI (mU3/L3) | 284±429 | 217±259 | 191±221 | −0.179 | 0.029 | 8×10−10 | ||
|
Helsinki Birth Cohort (OGTT n=1,600) |
CC | CG | GG | |||||
| AGE (yrs) | 61.6±3.0 | 61.5±3.0 | 61.6±3.1 | - | - | 0.96 | ||
| BMI (kg/m2) | 27.0±4.2 | 27.2±4.4 | 27.1±4.2 | - | - | 0.53 | ||
| Fasting P-glucose (mmol/l) | 5.41±0.55 | 5.55±0.56 | 5.59±0.53 | 0.34 | 0.096 | 0.019 | 3×10−7 | |
| CIR (mUxL/mmol2) | 209±196 | 175±150 | 177±188 | −0.109 | 0.027 | 5×10−5 | ||
| DI (mU3/L3) | 19646±21504 | 15552±15063 | 15699±17881 | −0.122 | 0.027 | 8×10−6 | ||
| Intact proinsulin/insulin | 0.51±0.26 | 0.52±0.26 | 0.55±0.24 | 0.024 | 0.009 | 0.005 | ||
|
METSIM (n=4,257) |
Age (yrs) | 59.3±5.8 | 59.4±5.8 | 59.1±5.7 | 0.36 | - | - | - |
| BMI (kg/m2) | 26.9±3.9 | 26.9±3.7 | 26.5±3.7 | −0.058 | 0.020 | 4.3×10−3 | ||
| Fasting P-glucose (mmol/L) | 5.6±0.5 | 5.7±0.5 | 5.8±0.5 | 0.165 | 0.022 | 9.4×10−14 | ||
| CIR (mU×L/mmol2) | 196±212 | 168±165 | 152±143 | −0.143 | 0.022 | 1.3×10−10 | ||
| DI (mU3/L3) | 21554±28426 | 17878±18235 | 16798±16461 | −0.128 | 0.022 | 9.8×10−9 | ||
|
Botnia (IVGTT n=505) FUSION (FSIGT n=522) |
CC | CG | GG | |||||
| FPIR | 297±195 | 259±194 | 237±139 | 0.27 | −0.065 | 0.023 | 0.004 | |
| AIR (pM×8 min) | 2632±1731 | 2064±1468 | 1554±1092 | 0.35 | −0.316 | 0.067 | 2×10−6 | |
Data are means ± SD. CIR=corrected early insulin response to glucose during OGTT. DI=disposition index. FPIR=first phase insulin response during IVGTT. AIR = acute insulin response during frequently-sampled intravenous glucose tolerance test (FSIGT). RA= risk allele.