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Growth inhibition of HCC cells by selected hit compounds
| IC50 (μM) a | ||||
|---|---|---|---|---|
| Compound | Hep3B | SK-Hep1 | HepG2 | MHCC97 |
| AV606 | 0.92 ± 0.30 | 15.1 ± 1.6 | 0.89 ± 0.13b | NDc |
| Fiduxosin | 13.9 ± 5.3 | > 40 | 17.9 ± 2.8 | > 40 |
| NSC45291 | 6.8 ± 2.3 | > 40 | > 40 | > 40 |
| Pimozide | 5.0 ± 0.4 | 19.9 ± 4.3 | 5.6 ± 0.8 | 10.8 ±0.08 |
concentration giving half-maximal growth inhibition (average ± sd, n = 3 plates, duplicate wells per plate). Highest concentration tested was 40 μM
range (n = 2)
not determined
