Table 3.
OC and QTc by Generation, Dose, and Route of Delivery
| Number of Women | QTc ± SD | P‐Value* | P‐Value** | |
|---|---|---|---|---|
| OC generation | ||||
| First | 15,719 | 400.8 ± 21.5 | P < 0.0001 | P < 0.0001 |
| Second | 9,303 | 399.2 ± 21.0 | ||
| Third | 5,762 | 400.8 ± 21.1 | ||
| Fourth | 3,890 | 403.5 ± 22.6 | ||
| Nonusers | 376,106 | 403.5 ± 22.6 | ||
| OC dose | ||||
| Very low | 571 | 402.0 ± 21.1 | P < 0.0001 | 0.1866 |
| Low | 33,747 | 400.7 ± 21.3 | ||
| Moderate | 157 | 402.7 ± 20.8 | ||
| Nonusers | 376,106 | 403.5 ± 22.6 | ||
| Route | ||||
| Oral | 34,118 | 400.7 ± 21.3 | P < 0.0001 | 0.4942 |
| Transdermal | 360 | 401.3 ± 21.4 | ||
| Vaginal | 198 | 402.4 ± 23.8 | ||
| Nonusers | 376,106 | 403.5 ± 22.6 |
OC = oral contraceptive use, QTc = corrected QT.
*Includes women not on OC (OC nonusers) in analysis.
**Includes only women on OC in analysis.