Table 5.

Effect of OC Generation on QTc Stratified by Comorbidity and Exposure to QTc‐Altering Drugs

		OC Generation*
		1		2		3		4
	n	Slope (SE)	P‐Value	Slope (SE)	P‐Value	Slope (SE)	P‐Value	Slope (SE)	P‐Value
OC users by generation vs. nonusers	410,782	−1.0 (0.18)	<0.0001	−2.0 (0.23)	<0.0001	0.6 (0.30)	0.051	3.6 (0.35)	<0.0001
No Comorbidities
No drugs	240,745	−1.2 (0.28)	<0.0001	−2.2 (0.28)	<0.0001	0.5 (0.33)	0.15	4.0 (0.43)	<0.0001
1 or more drugs	10,714	−1.0 (0.86)	0.23	−2.0 (0.11)	0.07	−2.4 (1.32)	0.07	2.0 (1.56)	0.19
1 or more comorbidities
No drugs	143,788	−0.8 (0.35)	0.02	−1.8 (0.47)	<0.0001	1.6 (0.68)	0.02	2.8 (0.71)	<0.0001
1 or more drugs	15,535	0.3 (0.94)	0.76	−2.2 (1.25)	0.07	1.3 (2.06)	0.52	0.2 (1.78)	0.90

*Relative to nonusers and adjusted for age, race/ethnicity and smoking status.

OC = oral contraceptive use, QT_c = corrected QT.