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Effect of t-BHP on whole-cell currents in Kir1.1b (ROMK2)-expressing Xenopus oocytes with [K+]o =1.0 mM, pHi ∼ 7.8. A: representative current traces, measured in response to voltages applied between −110 and +50 mV. Dashed line denotes zero current. Upward deflections from the dashed line denote outward current. B: current-voltage relations recorded in the same oocyte at different times after application of 500 μM tert-butyl hydroperoxide (t-BHP).
