Fig. 4.
Chronic infusion of EGF prevents development of hypertension in salt-sensitive (SS) rats fed a high-salt diet via downregulation of ENaC activity. A: effect of continuous intravenous EGF infusion on the mean arterial pressure in the SS rats fed a high-salt diet. B and C: representative single channel traces (B) and summary graph (C) for ENaC activity from freshly isolated split opened collecting ducts derived from SS rats after chronic treatment with EGF or vehicle. MAP, mean arterial pressure; NPo, average channel activity. [Reproduced from Ref. 82 with permission].