Fig. 3.

A and B: pancreatic collagen-4 mRNA and protein levels are significantly higher in APKO than WT mice with CP. C: apelin treatment (25 μg per ip injection, twice per day) during a 1-wk recovery period following CP induction suppresses CP-induced elevations of pancreatic collagen-1α1 expression in WT and APKO mice. C: pancreatic collagen-1α1 expression levels are significantly higher in vehicle- or apelin-treated APKO than corresponding WT mice. Values are means ± SE; n = 6 mice per group. *P < 0.05 vs. WT. †P < 0.05 vs. control/pre-CP. ΔP < 0.05 vs. CP + 1-wk recovery (vehicle-treated).