Fig. 4.

Effect of capsazepine (CZP) on the CT response to NaCl and NaCl + Bz. A and B: representative CT response to stimulation of the rat tongue first stimulated with a rinse solution (10 mM KCl) and then with 100 mM NaCl + RTX (0.25–10 μM) or 100 mM NaCl + 5 μM Bz + RTX (0.25–10 μM) in the absence (0 CZP) and presence of 10 μM CZP. C: in each case, the CT response was normalized to the corresponding tonic CT responses obtained with 300 mM NH₄Cl. Values are means ± SE of 3 animals. Mean normalized values at 0 and 1 μM RTX for 100 mM NaCl, 100 mM NaCl + 5 μM Bz, and 100 mM NaCl-(100 mM NaCl + 5 μM Bz) (the Bz-sensitive component of the NaCl CT response) and the RTX-induced increase in the CT response in the presence of 100 mM NaCl and 100 mM NaCl + 5 μM Bz are shown. *P < 0.001 vs. 0 RTX. D: mean normalized tonic CT responses at each RTX concentration in the absence (control) and presence of CZP. In the presence of CZP, the mean normalized tonic CT responses at 0.25, 0.5, and 1.0 μM RTX were significantly smaller than control: *P = 0.0004, 0.0001, and 0.0003, respectively.