Fig. 5.

CT responses in WT and transient receptor potential (TRP) subfamily M member 5 (TRPM5) knockout (KO) mice. A: CT responses of the mouse tongue during stimulation first with a rinse solution (10 mM KCl) and then with 10 and 20 mM quinine. B: quinine CT responses in WT and TRPM5 KO mice normalized to the corresponding CT responses obtained with 300 mM NH₄Cl. Values are means ± SE of 3 animals. C: CT responses during stimulation of the mouse tongue first with a rinse solution (10 mM KCl) and then with 300 mM NH₄Cl, 300 mM NaCl, 100 mM NaCl, and 100 mM NaCl + 5 μM Bz. In each mouse, the Bz-insensitive NaCl CT responses were normalized to the corresponding tonic CT responses obtained with 300 mM NH₄Cl. Values are means ± SE of number of animals in parentheses. *P = 0.0007; **P = 0.0001 (paired).