Fig. 7.

Summary of the normalized Bz-insensitive NaCl CT responses in WT, transient receptor potential vanilloid subfamily member 1 (TRPV1) KO, and TRPM5 KO mice. From similar experiments shown in Fig. 6, the Bz-insensitive NaCl CT responses were normalized to the corresponding CT responses obtained with 300 mM NH₄Cl. A: tonic responses of WT and TRPM5 KO mice and WT and TRPV1 KO mice to RTX. All mean normalized tonic 100 mM NaCl + 5 μM Bz CT responses in TRPM5 KO and TRPV1 KO mice in the absence and presence of RTX were significantly smaller than their corresponding values in WT mice (P < 0.0001, paired). B: normalized phasic 100 mM NaCl + 5 μM Bz CT responses of WT, TRPM5 KO, and TRPV1 KO mice in the absence and presence of 1 μM RTX. Values are means ± SE of 3 animals. *P = 0.0434; **P = 0.0094; ***P = 0.0009; ****P = 0.0001 (unpaired). Also shown is the mean normalized value of the mechanical rinse artifact (Rinse) in 3 TRPM5 KO mice. Normalized phasic 100 mM NaCl + 5 μM Bz CT responses in the absence of RTX in TRPV1 KO and TRPM5 KO mice and in the presence of 1 μM RTX in TRPV1 KO mice were not significantly different from the normalized value of the mechanical rinse artifact (P > 0.05).