Fig. 3.

Suppression of cytokine and growth factor induction in the liver after partial hepatectomy (PH) in ADAM17 h-KO mice, determined by specific ELISAs. A: levels of TNF in liver tissue after PH are significantly lower in ADAM17 h-KO mice (open bars) compared with controls (black bars) (n = 3–5). B: levels of TNFR1 are lower in liver tissue from ADAM17 h-KO mice compared with controls after PH (n = 3–5). C: levels of serum IL-6 are similar in ADAM17 h-KO mice and control mice after PH (n = 2–6). D: upregulation of amphiregulin protein is abrogated after PH in ADAM17 h-KO mice compared with controls (n = 3–6). Data are presented as means ± SE. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with Cre- controls; n = 3–5 mice.