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. 2013 May 9;305(1):G74–G83. doi: 10.1152/ajpgi.00086.2013

Fig. 3.

Fig. 3.

Representative images of immunofluorescence of SOX9 and IGFBP-4 in human normal colon (A) and primary cancer (B and C) specimens. A: representative images of immunofluorescence staining for SOX9 (green) and IGFBP-4 (red) on human normal colon sections. SOX9 and IGFBP-4 are colocalized in the lower crypt cells. Bottom: higher-magnification images corresponding to insets above. B: immunofluorescence showed colocalization of SOX9 and IGFBP-4 in SOX9-positive human colorectal cancer (CRC). Bottom: higher-magnification images corresponding to insets above. C: IGFBP-4 is significantly downregulated in SOX9-negative human CRC. DAPI, 4′,6-diaminido-2-phenylindole.