Fig. 6.

Sox9 deficiency in Apc^Min/+ mice resulted in increased tumor burden relative to Apc^Min/+ control mice. A: SOX9 and IGFBP-4 were highly expressed in most of the adenoma cells of Apc^Min/+ control mice (left), while neither SOX9 nor IGFBP-4 was detectable in Sox9-deficient Apc^Min/+ mice (right). B: Sox9 deficiency [Sox9 knockout (KO)] in Apc^Min/+ mice resulted in increased total number of adenomas relative to Apc^Min/+ wild-type (WT) mice (left). Number of larger (>1 mm²) adenomas significantly increased in Sox9-deficient Apc^Min/+ mice relative to their littermate controls (right).