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Downregulation and mislocalization of claudins (Cldn) in esophageal epithelium at 4 wk after duodenal or mixed reflux. A: real-time PCR of Cldn1 and Cldn4. Values are means ± SE. *P < 0.05 vs. control. B: Western blots of Cldn1 and Cldn4. C: quantitation of Cldn1 and Cldn4 Western blots. **P < 0.01 vs. control. D: immunohistochemical staining for Cldn1 and Cldn4.
