Table 3.
Genes identified by standard or reverse COMPARE analyses, whose mRNA expression in a panel of 60 cell lines correlated with IC50 values for hopeaphenol.
| Pearson's correlation coefficient | Experimental ID | Gene symbol | Name | Function |
|---|---|---|---|---|
| 0.552 | GC63503 | HMGN4 | High mobility group nucleosomal binding domain 4 | Binds nucleosomal DNA |
| 0.527 | GC190712 | UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | Nucleotidyltransferase |
| 0.521 | GC45602 | TBC1D2 | TBC1 domain family, member 2 | GTPase activator |
| 0.521 | GC188142 | ERBB2IP | Erbb2 interacting protein | Receptor adapter, structural constituent of cytoskeleton |
| 0.515 | GC26884 | PRPS1 | Phosphoribosyl pyrophosphate synthetase 1 | Involved in nucleotide synthesis |
| 0.513 | GC38343 | CNNTAL1 | Unknown | |
| −0.591 | GC97260 | MANBA | Mannosidase, beta A, lysosomal | Exoglycosidase |
| −0.574 | GC73531 | FGF9 | Fibroblast growth factor 9 (glia-activating factor) | Cell growth and differentiation during development |
| −0.534 | GC55495 | CYP7B1 | Cytochrome P450, family 7, subfamily B, polypeptide 1 | Monooxygenase |
| −0.516 | GC94617 | GABRA3 | Gamma-aminobutyric acid (GABA) A receptor, alpha 3 | Neurotransmission |
| −0.515 | GC184017 | HES1 | Hairy and enhancer of split 1, (Drosophila) | Transcriptional repressor |
Information on gene functions was taken from the OMIM database, NCI, USA, (http://www.ncbi.nlm.nih.gov/Omim/) and from the GeneCard database of the Weizmann Institute of Science, Rehovot, Israel (http://bioinfo.weizmann.ac.il/cards/index.html).