Table 4.
Genes identified by standard or reverse COMPARE analyses, whose mRNA expression in a panel of 60 cell lines correlated with IC50 values for deoxynarciclasine.
| Pearson's correlation coefficient | Experimental ID | Gene symbol | Name | Function |
|---|---|---|---|---|
| 0.572 | GC74997 | SNAP25 | Synaptosomal-associated protein, 25 kDa | Regulation of neurotransmitter release |
| 0.56 | GC32186 | OPTN | Optineurin | Maintenance of membrane trafficking |
| 0.557 | GC52658 | FAM116B | Family with sequence similarity 116, member B | Unknown |
| 0.531 | GC187393 | ZDHHC7 | Zinc finger, DHHCtype containing 7 | Palmitoyltransferase |
| 0.529 | GC12575 | CLEC9A | C-type lectin domain family 9, member A | Endocytic receptor for necrotic cells |
| 0.528 | GC188718 | SNX6 | Sorting nexin 6 | Involved in intracellular trafficking |
| 0.528 | GC154565 | RAB11FIP5 | RAB11 family interacting protein 5 (class I) | Involved in protein trafficking |
| 0.527 | GC18484 | NTAN 1 | N-terminal asparagine amidase | Ubiquitin-dependent turnover of intracellular proteins |
| 0.526 | GC16433 | DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | Endoplasmic reticulum cochaperone |
| 0.524 | GC10009 | PCOLCE2 | Procollagen C-endopeptidase enhancer 2 | Binds to procollagens |
| 0.524 | GC45803 | LMAN2L | Lectin, mannose-binding 2-like | Regulation of export from the endoplasmic reticulum |
| 0.524 | GC82947 | NGDN | Neuroguidin, EIF4E binding protein | Involved in the translational repression |
| 0.519 | GC75800 | SEC24D | SEC24 family, member D (S. cerevisiae) | Transport of ER-derived vesicles |
| 0.517 | GC90440 | KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | Retention of luminal endoplasmic reticulum proteins |
| 0.514 | GC173264 | GNA12 | Guanine nucleotide binding protein (G protein) α12 | Transducer in transmembrane signaling |
| 0.512 | GC170473 | MYBL1 | V-Myb myeloblastosis viral oncogene homolog (avian)-like 1 | Transcriptional activator |
| 0.512 | GC175225 | LPP | LIM domain containing preferred translocation partner in lipoma | Signal transduction from cell adhesion sites to the nucleus |
| 0.511 | GC14006 | ITGB5 | Integrin, β5 | Receptor for fibronectin |
| 0.509 | GC150035 | DCBLD2 | Discoidin, CUB, and LCCL domain containing 2 | Involved in tumor progression |
| 0.508 | GC73833 | NCEH1 | Neutral cholesterol ester hydrolase 1 | Promotes tumor cell migration |
| 0.507 | GC177466 | AHNAK | AHNAK nucleoprotein | Involved in neuronal cell differentiation |
| 0.502 | GC40315 | ADAL | Adenosine deaminaselike | Putative nucleoside deaminase |
| 0.502 | GC28174 | MPG | N-methylpurine-DNA glycosylase | Hydrolysis of alkylated DNA |
| 0.501 | GC18079 | CR1 | Complement component (3b/4b) receptor 1 (Knops blood group) | Mediates cellular binding of particles and immune complexes |
| −0.658 | GC18354 | ILF2 | Interleukin enhancer binding factor 2, 45 kDa | Transcription |
| −0.608 | GC44240 | NDUFA2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8 kDa | Part of mitochondrial membrane respiratory chain |
| −0.605 | GC65788 | HNRNPA1 | Heterogeneous nuclear ribonucleoprotein A1 | Involved in RNA replication |
| −0.589 | GC43237 | CWF19L1 | CWF19-like 1, cell cycle control (S. pombe) | Cell cycle control |
| −0.572 | GC174320 | BCLAF1 | BCL2-associated transcription factor 1 | Death-promoting transcriptional repressor |
| −0.572 | GC40779 | LARS | Leucyl-tRNA synthetase | Editing of tRNA |
| −0.567 | GC151509 | FRAT2 | Frequently rearranged in advanced T-cell lymphomas 2 | Wnt signaling regulator |
| −0.561 | GC175610 | IK | IK cytokine, downregulator of HLA II | May bind to chromatin |
| −0.555 | GC30213 | SLN | Sarcolipin | Sarcoplasmic reticulum proteolipid |
| −0.553 | GC162737 | ANKHD2 | Unknown | |
| −0.552 | GC17532 | SFRS28 | Unknown | |
| −0.55 | GC185046 | SFRS1 | Serine/arginine-rich splicing factor 1 | Splicing regulator |
| −0.55 | GC37292 | FARSA | Phenylalanyl-tRNA synthetase, α subunit | Phenylalanine-tRNA ligase |
| −0.548 | GC32318 | MKI67 | Antigen identified by monoclonal antibody Ki-67 | Cell proliferation |
| −0.548 | GC149101 | MATR3 | Matrin 3 | Regulator of transcription |
| −0.547 | GC150688 | PSPC1 | Paraspeckle component 1 | Regulator of androgen receptor-mediated gene transcription |
| −0.546 | GC80581 | ZBTB11 | Zinc finger and BTB domain containing 11 | Regulator of transcription |
| −0.546 | GC52470 | MLF1IP | MLF1 interacting protein | Involved in mitotic progression |
| −0.545 | GC81490 | NUDT21 | Nudix (nucleoside diphosphate linked moiety X)-type motif 21 | Involved in pre-mRNA 3′-processing |
| −0.543 | GC33504 | DDX39 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A | Involved in pre-mRNA splicing |
| −0.543 | GC35760 | NDUGB8 | Unknown | |
| −0.539 | GC36766 | CHUK | Conserved helix-loop-helix ubiquitous kinase | Involved in NF-kappa-B signaling |
| −0.538 | GC33463 | POLD1 | Polymerase (DNA directed), δ1, catalytic subunit | DNA synthesis |
| −0.537 | GC83208 | SERBP1 | SERPINE1 mRNA binding protein 1 | Regulation of mRNA stability |
| −0.536 | GC153558 | CNOT8 | CCR4-NOT transcription complex, subunit 8 | Transcription factor |
| −0.535 | GC17771 | GOT1 | Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | Involved in amino acid metabolism |
| −0.535 | GC43091 | NUDCD2 | NudC domain containing 2 | Unknown |
| −0.534 | GC31949 | HSPA9 | Heat shock 70 kDa protein 9 (mortalin) | Control of cell proliferation and cellular aging |
| −0.533 | GC91403 | IKZF5 | IKAROS family zinc finger 5 (Pegasus) | Transcriptional repressor |
| −0.533 | GC31641 | SF1 | Splicing factor 1 | Transcriptional repressor |
| −0.532 | GC161453 | KDM2B | Lysine (K)-specific demethylase 2B | Histone demethylase |
| −0.53 | GC35520 | EBP | CCAAT/enhancer binding protein (C/EBP), gamma | Transcription factor |
| −0.53 | GC10226 | ABCB7 | ATP-binding cassette, sub-family B (MDR/TAP), member 7 | Heme transport |
Information on gene functions was taken from the OMIM database, NCI, USA, (http://www.ncbi.nlm.nih.gov/Omim/) and from the GeneCard database of the Weizmann Institute of Science, Rehovot, Israel (http://bioinfo.weizmann.ac.il/cards/index.html).