Table 5.
Separation of clusters of 60 cancer cell lines obtained by hierarchical cluster analysis for hopeaphenol and deoxynarciclasine. The log10 IC50 median values (M) of each compound were used as cut-off values to define cell lines as being sensitive or resistant. P > 0.05 was considered as not significant (χ 2 test).
| Sensitive | Resistant | χ 2 test | |
|---|---|---|---|
| Hopeaphenol | |||
| Partition* | <−5.80 | >−5.80 | |
| Cluster 1 | 0 | 7 | |
| Cluster 2 | 0 | 4 | |
| Cluster 3 | 15 | 0 | |
| Cluster 4 | 12 | 16 | P = 4.49 × 10−6 |
|
| |||
| Deoxynarciclasine | |||
| Partition* | <−6.40 | >−6.40 | |
| Cluster 1 | 3 | 22 | |
| Cluster 2 | 13 | 2 | |
| Cluster 3 | 7 | 0 | P = 1.76 × 10−6 |
*log10 IC50 (M).