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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: Clin Cancer Res. 2013 May 29;19(14):3764–3775. doi: 10.1158/1078-0432.CCR-12-3725

Figure 7.

Figure 7

S100B upregulation stimulates CCL2 expression and TAM trafficking into i.c. K-luc gliomas. To validate our findings in a second glioma model, a monoclonal K-luc glioma cell line that overexpressed S100B was generated and assessed for CCL2 production. A, K-luc-S100Bhigh, but not control cells that were transfected with blank plasmid (K-luc-S100Bwt), expressed higher levels of CCL2 in vitro (n=3/group, ±SD, * : p < 0.05). B, Ten-day old i.c. K-luc-S100Bhigh gliomas expressed higher levels of S100B (top panel, red stain) and exhibited stronger TAM infiltration (CD11b staining, green stain) as compared to K-luc-S100Bwt tumors. Most of the S100B expression in the K-luc-S100Bwt was in the astrocytes (arrows) adjacent to the invasive tumor edge. (n=2 mice/group). T: tumor.