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. Author manuscript; available in PMC: 2014 Mar 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2013 Jan 23;267(3):276–283. doi: 10.1016/j.taap.2013.01.005

Fig. 1.

Fig. 1

BER activity in the splenic NEs of control and aniline-treated rats. The assay was conducted with end-labeled oligonucleotides (Tg:G) which are targeted by NTH1 (see methods for details). (A) Autoradiogram of incision products (P) generated over time by cleavage of end-labeled double-stranded oligonucleotides carrying the Tg lesion adducts (S). Negative control (without NEs) and positive control (recombinant NTH1) are included in the external lanes. (B) Values from Phosphorimager quantitation of products, generated with NEs from 5 rats per group and 3 cleavage assays per extract, were averaged and plotted as means ± SD. * Indicates that the cleavage is significantly different from controls for each respective time point (p < 0.05).