Table 1.
Evidence for nuclear localization of NF2
| Regulation of nuclear translocation | Reference | Detection method* | Cell types examined | Species |
|---|---|---|---|---|
| Phosphorylation of Ser 518 | Lü et al. (2008) | IF and IHC | neurons | human |
| Thaxton et al. (2007) | IF | schwannoma | human | |
| Li et al. (2010) | IF | mesothelioma | human | |
| squamous carcinoma | ||||
| Schwann (immortalized) | ||||
| mammary epithelial | ||||
| umbilical vein endothelial | ||||
| schwannoma | mouse | |||
| G1 phase of cell cycle | Muranen et al. (2005) | NT, IF, NF, WB | glioma | human |
| IF, NF, WB | osteosarcoma | |||
| NF, WB | embryonal kidney | |||
| Unknown | Kressel and Schmucker (2002) | NT and IF | embryonic fibroblasts | mouse |
| Shollar et al. (2004) | IF, IHC, NF, WB | malignant peripheral nerve sheath | mouse | |
| Beltrami (unpublished) | IHC | glioblastoma | human | |
*
IF: immunofluorescence; IHC: immunohistochemistry; NF: nuclear fractionation; NT: nuclear trapping; WB: western blotting