Table 1.

Gene ontology terms correlated with cluster A (Ras, b-catenin, CCS, Wound healing)

Type	CAC vs. NL	CAC vs. IBD	Correlation	Gene set
	ΔS	ΔS
BP	0.49	0.55	0.95	Mitotic cell cycle
	0.41	0.45	0.95	Cell division
	0.56	0.66	0.95	M phase of mitotic cell cycle
	0.57	0.66	0.95	Mitotic prometaphase
	0.70	0.75	0.89	Mitotic spindle organization
	0.47	0.54	0.88	Cell cycle checkpoint
	0.67	0.75	0.88	DNA strand elongation involved in DNA replication
	0.49	0.64	0.87	mitotic sister chromatid segregation
	0.48	0.66	0.86	CenH3-containing nucleosome assembly at centromere
	0.49	0.66	0.86	Telomere maintenance via recombination
	0.52	0.56	0.86	Regulation of transcription involved in G1/S phase of mitotic cell cycle
	0.43	0.53	0.85	S phase of mitotic cell cycle
	0.50	0.67	0.85	Telomere maintenance via semi-conservative replication
	0.43	0.51	0.83	Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
	0.42	0.59	0.82	Nucleotide-excision repair, DNA gap filling
	0.46	0.54	0.81	M/G1 transition of mitotic cell cycle
	0.42	0.50	0.80	Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
	0.47	0.67	0.80	DNA-dependent DNA replication initiation
	0.41	0.49	0.79	Double-strand break repair via homologous recombination
	0.49	0.49	0.78	Mitotic cell cycle spindle assembly checkpoint
	0.65	0.78	0.77	Chromosome organization
	0.44	0.47	0.73	Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
	0.53	0.41	0.71	RNA metabolic process
MF	0.48	0.56	0.76	ATP-dependent DNA helicase activity
	0.41	0.53	0.75	Nuclease activity
	0.47	0.67	0.71	DNA helicase activity
CC	0.45	0.56	0.93	Condensed chromosome kinetochore
	0.41	0.53	0.89	Kinetochore
	0.44	0.40	0.89	Apindle pole
	0.42	0.57	0.87	Condensed chromosome
	0.52	0.53	0.85	Spindle microtubule
	0.46	0.42	0.77	Ribonucleoprotein complex
	0.55	0.47	0.72	U12-type spliceosomal complex

Note: CAC, cholangiocarcinoma; NL, normal liver; IDB, intrahepatic bile duct; BP, Biological process; MF, Molecular function; CC, Cellular component; ΔS difference of S-score