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. 2012 Sep 28;1:22. doi: 10.1186/2193-1801-1-22

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© O’Shannessy et al.; licensee Springer. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Triple negative [ER/PR/Her2(−)] poorlydifferentiated ductal carcinoma.a Tumor cells are arranged in solid nests and present with high nuclear grade, prominent nucleoli and active mitosis. Cell borders are ill-defined. There are scattered apoptotic cells with pyknotic nuclei and densely eosinophilic cytoplasm (x20). b In the immunohistochemical stain for FRA, about 60% of tumor cells demonstrate membrane staining ranging from 1+ to 3+ (x20).