Table 3.
Neuropsychological findings of confirmed AD and 5 subtypes of Alzheimer mimics at the last examination.
| Confirmed AD (n=414) | Alzheimer mimics (n=119) | p value* | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| DLB (n=35) | Insufficient AD (n=22) | Vascular D. (n=15) | FTLD (n=14) | HS (n=10) | p value† | ||||
| MMSE | 12.74±15.26 | 16.97±8.29 | 0.02 | 13.81±9.24 | 19.82±8.47 | 21.23±5.18 | 10.83±9.55 | 17.78±5.72 | <0.001 |
| Logical Memory IA-Immediate | 2.26±2.84 | 5.11±4.41 | <0.001 | 4.86±4.70‡ | 6.27±4.15‡ | 6.55±4.74‡ | 4.50±1.73 | 3.13±2.36 | <0.001 |
| Logical Memory IIA-Delayed | 1.04±2.15 | 2.86±4.03 | <0.001 | 3.19±4.20‡ | 4.73±4.63‡ | 3.00±2.94 | 0.75±0.96 | 1.13±1.55 | <0.001 |
| Digit Span Forward | 5.13±1.89 | 5.96±1.36 | 0.002 | 5.43±1.89 | 6.42±1.24 | 6.38±0.96 | 5.80±0.84 | 6.13±1.25 | 0.016 |
| Digit Span Backward | 2.84±1.54 | 3.47±1.37 | 0.01 | 2.80±1.19 | 3.58±1.08 | 4.08±1.04‡ | 3.00±0.71 | 3.501.93 | 0.041 |
| Category Fluency | |||||||||
| Animals | 6.43±4.84 | 8.65±4.67 | 0.001 | 8.08±4.99 | 9.00±5.13 | 9.38±4.77 | 7.00±3.39 | 7.75±3.15 | 0.075 |
| Vegetables | 3.77±3.33 | 5.51±3.27 | <0.001 | 4.87±3.65 | 6.30±2.75 | 5.62±3.82 | 5.40±2.51 | 5.50±3.16 | 0.019 |
| Trail Making Test (sec) | |||||||||
| Part A | 97.54±44.96 | 96.98±42.44 | 0.954 | 124.95±80.82 | 80.73±42.08 | 91.73±51.08 | 61.50±23.10 | 100.63±41.66 | 0.036 |
| Part B | 244.29±80.82 | 237.32±80.10 | 0.628 | 300.00±0.00 | 198.88±81.55 | 200.33±90.89 | 216.25±97.88 | 237.50±109.59 | 0.074 |
| WAIS-Digit Symbol | 18.94±17.12 | 19.56±12.28 | 0.827 | 9.50±7.113 | 22.45±15.43 | 20.00±11.94 | 30.75±8.06 | 17.86±7.27 | 0.04 |
| BNT | 14.88±8.65 | 18.96±7.33 | <0.001 | 18.22±7.70 | 20.27±7.03 | 16.15±8.20 | 19.33±6.19 | 20.63±5.45 | 0.067 |
Values are presented as mean±standard deviation.
*
Comparisons between confirmed AD and Alzheimer mimics by Student t-test.
†
Comparisons among dementia subtypes such as confirmed AD, DLB, insufficient AD, vascular disease, FTLD, and HS by analysis of covariances
‡
Significant difference after multiple comparisons by Scheffee method, compared to confirmed AD.
Age was adjusted for the analyses.
AD, Alzheimer’s Disesae; DLB, dementia with Lewy body; FTLD, fontotemporal lobar degeneration; HS, hippocampal sclerosis; MMSE, mini-mental state examination; WAIS, Wechsler Adult Intelligence Scale; BNT, Boston naming test.