Table 1.

Inhibition of nicotine-evoked [³H]DA release from superfused rat striatal slices.

Compound			DA Release
	Head group	Linker	Inhibition (100 nM)a	IC50 (nM) and Imaxbb
bPiDDB 1		bis-1,12-dodecane	NDc	2.0±1.0d 63%
bPiDB 8		bis-1,10-decane	ND	180±110 63%
tPy3PiB 3		tris-linker (unsaturated)	40±12%	0.2±0.07e 67%
7		bis-1,12-dodecane	50±21%	0.95±0.30 60%
9		bis-1,10-decane	36±12%	37.4±18.7 65%
16		tris-linker (unsaturated)	83±2%	3.22±1.36 67%
bPyiQB 2		rigid bis-linker	ND	63±39f 59%
12		bis-1,12-dodecane	ND	40±30 53%
13		bis-1,10-decane	ND	70±50 95%
18		tris-linker (saturated)	28±11%	ND
21		tetrakis-linker	ND	56±45 52%
11		rigid bis-linker	18±18%	ND
14		bis-1,12-dodecane	ND	8.59±3.27 76%
15		bis-1,10-decane	ND	9.91±9.23 74%
19		tris-linker (saturated)	58±9%	0.35±0.09 58%
22		tetrakis-linker	84±4%	205±132 64%
tkP3HPPB 4		tetrakis-linker	41±15%	3.0±3.0g 63%
23		tetrakis-linker	40±23%	30±16 64%

^aPercentage inhibition at 100 nM is presented unless otherwise specified. Each value represents data from at least 3 independent experiments, each performed in duplicate.

^bIC₅₀ and I_max from full concentration response assays; data from 4–6 independent experiments.

^cNot determined;

^dtaken from results published in ref 15;

^etaken from results published in ref 13;

^ftaken from results published in ref 12;

^gtaken from results published in ref 14.