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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: Bioorg Med Chem Lett. 2010 May 4;20(12):3584–3587. doi: 10.1016/j.bmcl.2010.04.117

Table 2.

Pharmacological activity at VMAT2 of analogues 14, 21–24 in comparison with 1

Analogue [3H]-DTBZ; Ki ± SEM (μM) VMAT2 [3H]DA uptake Ki ± SEM (μM)
1•0.5 H2SO4 0.97 ± 0.19 0.045 ± 0.002
14 33.3 ± 16.3 3.72 ± 0.32
21 5.87 ± 1.72 5.23 ± 3.03
22•HCl 0.96 ± 0.37 0.067 ± 0.015
23•HCl 2.64 ± 1.41 0.051 ± 0.005
24•C4H4O4 26.01 ± 2.88 2.13 ± 0.28