Skip to main content
. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7878–7882. doi: 10.1021/jm900770h

Scheme 1. Synthesis of 2,5-diphenethylpyrrolidines.

Scheme 1

Reagents and conditions. a. Ph-(CH2)n-MgBr (6 equiv.), THF, 0 °C to rt, 8 h; b. Silica gel chromatographic separation. c. HCI, ether d. NH4COO, Pd(OH)2/C, MeOH, reflux, 20 min. then conc. HCI; e. paraformaldehyde, Na(OAc)3BH, CH3CN, rt, 4h;