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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: J Med Chem. 2009 Dec 10;52(23):7878–7882. doi: 10.1021/jm900770h

Scheme 2. Synthesis of second-generation pyrrolidine analogs.

Scheme 2

Reagents and conditions. a. R-MgX, MgBr2 (10 equiv), THF, rt. b. Pd(OH)2, NH4COO, CH3OH, c. Na(OAc)3BH, CH3CN, paraformaldehyde