Table 1.

Relative survival of cultured HT-29 cells and the relative potency of the substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one analogs at 150 µM concentration.

Compound	Relative survival* of HT-29 cells at 41° C	Relative potency**
9a	1.00	1.00
9b	1.00	1.00
9c	0.98	1.00
9d	1.00	1.00
9e	1.00	1.00
9f	0.56	1.79
9g	0.71	1.41
9h	0.86	1.00
9i	1.00	1.00
9j	0.81	1.00
9k	0.96	1.00
9l	0.75	1.00
1	0.50	2.00
Vehicle	1.00	1.00

^*Relative survival was calculated by correcting for vehicle effects and effect of drugs at 37° C.

^**Relative potency is equal to the reciprocal value of relative survival value, and is statistically significant from vehicle control (p < 0.05 Student's t test).