FIG. 2.

UBM treatment decreases the traumatic brain injury (TBI)-induced lesion area. (A) Representative hematoxylin and eosin-stained coronal sections near the injury epicenter from sham-operated, vehicle-, and UBM-treated rats 21 days following TBI. These sections are examples from three different treated animals at the anterior to posterior (AP) coordinates with respect to bregma (top to bottom). (B) The percentage of lesion volume compared to contralateral volume was significantly decreased in UBM- compared to vehicle-treated rats. Of note, UBM-treated rats had a significantly increased lesion volume compared to sham-operated controls. (C) Examination of the distribution of lesion showed that the tissue was mainly spared at around AP −2.6 to −4.0 mm in the UBM-treated group. Bars represent mean±standard error (SE) with an n=6, 10, and 12, for sham-, UBM-, and vehicle-treated groups, respectively. Scale bars: 5 mm. *p<0.05. Color images available online at www.liebertpub.com/tea