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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: Eur J Neurosci. 2005 Jun;21(12):3427–3438. doi: 10.1111/j.1460-9568.2005.04159.x

Fig. 3.

Fig. 3

Effect of SB-277011A on cocaine self-administration under PR reinforcement. (A,B) Representative records of an individual animal, illustrating the effects of SB-277011A (24 mg/kg, i.p.) on the PR break point for cocaine self-administration. Each short upward mark on the cumulative lever-press records indicates one cocaine infusion. The PR break point was defined as the last completed ratio requirement (lever-presses) for a unit dose of infused cocaine. (C) Mean cocaine dose-dependent self-administration under PR reinforcement, illustrating the cocaine-dose-orderly reduction in PR break point produced by SB-277011A (24 mg/kg, i.p., n = 6 for each cocaine dose group). *P < 0.05, ***P < 0.001, individual group comparison between vehicle and SB-277011A, using the Tukey (a) statistic. (D) Percentage change in PR break point for cocaine self-administration (0.5 mg/kg/infusion) produced by 6, 12 or 24 mg/kg SB-277011A pretreatment on test day compared to PR break point for cocaine self-administration after vehicle pretreatment on test day. *P < 0.05, ***P < 0.001, individual group comparisons using the Tukey (a) statistic, when compared to the vehicle (Veh) pretreatment group.