Fig. 4.
Effects of the mixed D3 agonist/antagonist BP 897 on cocaine cue-induced reinstatement of drug-seeking behavior. Pre-treatment with BP 897 significantly inhibited cocaine cue-induced reinstatement of drug-seeking behavior (A (right): F3,49 = 4.10, P < 0.05). Between-group comparisons with the Dunnett statistic revealed a statistically significant reduction in cocaine cue-induced drug-seeking after 3.0 mg/kg, but not 0.1 or 1.0 mg/kg BP 897 administration, when compared with the vehicle pretreatment group. In contrast, BP 897 had no significant effect on inactive lever presses during reinstatement testing (B: right).