Fig. 4.

The effects of S33138 on cocaine-triggered reinstatement. Panel A shows the general experimental protocol for cocaine-triggered reinstatement of drug-seeking behavior. Panel B shows the active lever presses during the last session of cocaine self-administration, the last session of extinction, and reinstatement testing after different doses of S33138. Panel C shows the inactive lever presses during the last session of cocaine self-administration, the last session of extinction, and reinstatement testing after different doses of S33138. Cocaine (10 mg/kg, i.p.) priming-induced reinstatement of drug-seeking behavior was dose-dependently inhibited by S33138 (0.156, 0.625, 2.5 mg/kg, p.o., 30 min prior to cocaine priming). **p < 0.01, ***p < 0.001, when compared with the vehicle control group.