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. Author manuscript; available in PMC: 2013 Jul 29.
Published in final edited form as: Pharmacol Biochem Behav. 2010 Dec 2;98(1):12–20. doi: 10.1016/j.pbb.2010.11.023

Figure 8.

Figure 8

Effects of higher ambient temperature (37°C) on core body temperature of animals treated with AC927 (10 mg/kg, i.p.) in the presence or absence of methamphetamine (5 mg/kg, i.p.). Male, Swiss Webster mice (N = 5–6 per group) were pretreated with saline or AC927 (10 mg/kg, i.p.) at 37°C. The mice were then challenged 15 min later with saline or methamphetamine (5 mg/kg, i.p.). This schedule of treatment was repeated at 2 h intervals, a total of four times. For comparison, some animals were treated with Saline + Saline, or Saline + Methamphetamine (5 mg/kg) at room temperature. Core body temperature was measured 1 h after each methamphetamine injection and data were reported as mean ± S.E.M. **P < 0.01, ***P < 0.001 vs. methamphetamine at room temperature (RT, 22°C).