Table 3.
Pharmacodynamic Parameters for Lymphocytopenia Induced by MPL
| Parameter (Unit) | Definition | Estimate | %SEM |
|---|---|---|---|
| Structural | |||
| kout (h−1) | Blood to tissue trafficking rate constant | 0.548 | 16.5 |
| IC50_M (ng/mL) | MPL concentration at 50% maximum inhibition | 29.5 | 30.5 |
| LYMB (0) (K/µL) | Blood compartment lymphocyte baseline | 7.8 | Fixed |
| LYMT (0) (K/µL) | Tissue compartment lymphocyte baseline | 400 | Fixed |
| BaselineC (%) | Baseline ratio between control and treated animals | 68.5 | 10.9 |
| kin (h−1) | Tissue to blood trafficking rate constant | 0.0115 | 20.2 |
| k (1/(ng/mL/h)) | Second-order cell loss rate constant | 0.000258 | 16.8 |
| IC50_C (ng/mL) | CS concentration at 50% maximum inhibition | 590 | NAa |
| Residual variability | |||
| Additive (K/µL) | Additive random error | 1.11 | 19.9 |
a
Secondary parameter.