. Author manuscript; available in PMC: 2013 Jul 29.

Published in final edited form as: Pharm Res. 2011 Mar 1;28(7):1622–1630. doi: 10.1007/s11095-011-0396-7

Table I.

Pharmacokinetic Parameter Estimates for Etanercept in CIA Rats

Parameter	Definition	Estimate	CV%
CL_D (mL/day/kg)	Distributional clearance	1.15	759
V₁ (mL/kg)	Volume of central compartment	46.3	3.19
V₂ (mL/kg)	Volume of peripheral compartment	53.9	1722
V_max (µg/day)	Capacity Michaelis-Menten constant	1200	143
K_m (µg/mL)	Affinity Michaelis-Menten constant	59.5	104
k_a (day⁻¹)	First-order absorption rate constant	1.41	72.4
F	Bioavailability of SC administration	0.42	7.93
Fr	Fractional dose undergoing k₁ process	0.201	330
T (day)	Time period for k₀ process	3	FIXED

CV% coefficient of variation percentage